The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
نویسندگان
چکیده
A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 11 2 شماره
صفحات -
تاریخ انتشار 2001